Modified whale’s tail technique using amnion membrane for periodontal regeneration in the anterior teeth with diastema: A case report

The biggest challenge during periodontal regeneration in the anterior region lies in the maintenance of esthetics. Whale’s tail technique has a novel flap design that achieves both these goals while maintaining the functional integrity of the periodontal tissues. A 46-yearold male reported with the chief complaint of bleeding from the gums. Periodontal examination of 11 shows probing pocket depth of 7 mm mesially with clinical attachment loss of 8 mm. Whale’s tail technique using demineralized freeze-dried bone allograft (DFDBA) and Amnion membrane was used in this case to achieve 4mm gain in clinical attachment level at the end of 11 months. This technique successfully demonstrates stable clinical outcomes in terms of management of anterior periodontal regeneration in diastema cases. Long term clinical trials are required to validate these results

Covid-19 Detection For CT-scan Images Using Transfer Learning Models

COVID-19 is a respiratory illness caused by a virus called SARS-CoV-2 which affected around 455 million people around the world. CT-scan is a medical imaging technique that uses X-rays to create detailed images of the body and which can be used to detect many respiratory diseases. Transfer learning models are a type of machine learning model that are trained on a large dataset of images and which can be used for their already trained ability to extract features from image in other tasks. They can then be used to classify new images with similar features.This paper presents a study of different transfer learning models for the task of classifying chest X-ray images into three classes: COVID-19, pneumonia, and normal. The study was implemented using Python and the dataset used was the COVID-19 Chest X-ray Dataset. The train-test split used was 0.2–0.8. The parameters used to test the models were the precision, recall, accuracy, F1 score, and Matthew’s correlation score. Other than these, different optimizers were also compared such as ADAM, SGD with different learning rates of 0.01, 0.001, and 0.0001.The models used in this study are EfficientNetB0, EfficientNetB7, VGG16, and InceptionV3. Out of these models, the most effective model was the EfficientNetB0 model, which achieved an accuracy of 98.6%. This study provides valuable insights into the use of transfer learning for medical image analysis. The results suggest that transfer learning can be used to develop accurate and efficient models that can be used as a secondary option for the diagnosis of COVID-19 using chest X-ray images

Study of Properties of Al LM-25/SIC fabricated by using Stir Casting Method and Wear Analysis by RSM

Aluminum MMC’s are widely used in various applications because of their higher mechanical and physical properties when compared with their base Al alloy. This paper focuses on the change in mechanical properties of various Al/SiC composites fabricated by using stir casting method. Effect of SiC reinforcement in different Al alloys on mechanical properties like hardness, tensile strength, wear test, percentage elongation, residual stress measurements are discussed in detail. For this purpose various reinforcement of SiC with 0,4,8 percent weight and different particle sizes are considered along with Al alloys. Variations in process parameters of stir casting are also made and taken into consideration

Ethnomedical uses, Phytochemistry, Pharmacological and therapeutic properties of Desmodium gangeticum (L.) DC.: A Scoping Review

A surge in laboratory research into the pharmacological properties of bioactive compounds, as well as their potential to cure a wide range of ailments, has resulted in an influx of new herbal medications and extracts onto the international market in recent years. D. gangaticum (L.) (DG), one of the essential herbs of Indian traditional system of medicines is part of many essential formulations viz. "Dashamoola" and is used to treat various diseases. It is a perennial herb, locally known as "Shalparni" (Hindi) in India and also reported in many other tropical countries. This review presents the traditional uses, phytochemistry, pharmacology, and clinical effectiveness of D. gangaticum Literature was systematically searched through various databases, journals and gray literature through electronic and manual search. Collected data was further critically reviewed and summarized in this paper. It contains many bio-active phytochemicals viz. gangeticoside, leonuriside A, tortoside A, dehydrosoyasaponin, gangetin, gangetinin, desmocarpin, desmodin etc. among them, some have drug likeliness properties. Critical literature analysis revealed that it possessed many pharmacological activities viz. anti-inflammatory, antinociceptive, anti- oxidant, cardioprotective, antidiabetic and hepatoprotective anti- bacterial, and anti-amnesic activities. Despite a large number of traditional therapeutic uses, D. gangaticum was evaluated for limited therapeutic efficacy through clinical trials and evidence suggested it may have therapeutic benefits on bronchitis, gout, hypertension. The biochemical and physiological mechanisms involved in the different biological effects exhibited by it need to be investigated. The herb should be investigated further, focusing on pharmacodynamic, pharmacokinetic and safety profiles. Well-designed Randomized Controlled trials (RCTs) should be conducted to support its therapeutic use

Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial

Background: Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. Methods: We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency abdominal surgery cases, and contributed data to the National Emergency Laparotomy Audit) were organised into 15 geographical clusters and commenced the QI programme in a random order, based on a computer-generated random sequence, over an 85-week period with one geographical cluster commencing the intervention every 5 weeks from the second to the 16th time period. Patients were masked to the study group, but it was not possible to mask hospital staff or investigators. The primary outcome measure was mortality within 90 days of surgery. Analyses were done on an intention-to-treat basis. This study is registered with the ISRCTN registry, number ISRCTN80682973. Findings: Treatment took place between March 3, 2014, and Oct 19, 2015. 22 754 patients were assessed for elegibility. Of 15 873 eligible patients from 93 NHS hospitals, primary outcome data were analysed for 8482 patients in the usual care group and 7374 in the QI group. Eight patients in the usual care group and nine patients in the QI group were not included in the analysis because of missing primary outcome data. The primary outcome of 90-day mortality occurred in 1210 (16%) patients in the QI group compared with 1393 (16%) patients in the usual care group (HR 1·11, 0·96–1·28). Interpretation: No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care. Funding: National Institute for Health Research Health Services and Delivery Research Programme

Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial

BACKGROUND: Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. METHODS: We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency abdominal surgery cases, and contributed data to the National Emergency Laparotomy Audit) were organised into 15 geographical clusters and commenced the QI programme in a random order, based on a computer-generated random sequence, over an 85-week period with one geographical cluster commencing the intervention every 5 weeks from the second to the 16th time period. Patients were masked to the study group, but it was not possible to mask hospital staff or investigators. The primary outcome measure was mortality within 90 days of surgery. Analyses were done on an intention-to-treat basis. This study is registered with the ISRCTN registry, number ISRCTN80682973. FINDINGS: Treatment took place between March 3, 2014, and Oct 19, 2015. 22 754 patients were assessed for elegibility. Of 15 873 eligible patients from 93 NHS hospitals, primary outcome data were analysed for 8482 patients in the usual care group and 7374 in the QI group. Eight patients in the usual care group and nine patients in the QI group were not included in the analysis because of missing primary outcome data. The primary outcome of 90-day mortality occurred in 1210 (16%) patients in the QI group compared with 1393 (16%) patients in the usual care group (HR 1·11, 0·96-1·28). INTERPRETATION: No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care. FUNDING: National Institute for Health Research Health Services and Delivery Research Programme

The An Event Driven Campus Navigation System On Android Platform

This paper presents the event based campus navigation system that we are build an android application which helps to candidates/persons to navigate to an event which is being organised in a campus.This application is developed for all the colleges to enter their event details or college workshops or gatherings dates,timings and fees so that it can be viewable to all the students of different colleges and becomes an easy way to participate through this application.There is no such system to inform all existing as well as outside students,teachers and staff to inform about any event very quickly with its proper place,which may start few minutes or few hours later and the structure of fees.As a result there is a high opportunity to miss any valuable event.To reduce this pain inside a university campus,a very user friendly Google map based Event-driven campus navigation system on android platform has been designed,implemented and tested successfully in this work.This application provides route guide forusers from his/her own location to desired location and event updates with its proper place

Hepatoprotective effect of Cocculus hirsutus on bile duct ligation-induced liver fibrosis in Albino Wistar rats

In this animal model (Wistar rats of either sex) common bile duct was ligated for 28 days. Rats were treated for 28 days with methanol extract of Cocculus hirsutus. On day 29, blood and liver were collected for biochemical estimation and histopathological studies. Bile duct ligation produced liver fibrosis with generation reactive oxygen species and induction of oxidative stress hence the different concentrations of methanolic extract of C. hirsutus were evaluated for in vivo glutathione reductase activity. On bile duct ligation the liver fibrosis was induced with significant rise in serum marker enzymes levels. The hydroxyproline accumulation caused by hydrophilic bile acids accompanied by elevated hepatic lipid peroxidation, and glutathione levels. Treatment with C. hirsutus decreased the elevated levels of serum marker enzymes showing hepatoprotection, which was further confirmed by histopathological results